Here, we report a cryo-electron microscopy study of uromodulin (UMOD)/Tamm–Horsfall protein, the most abundant protein in human urine and an archetypal ZP module-containing molecule, in its mature homopolymeric state.
Despite the conservation of this element from hydra to humans, no detailed information is available on the filamentous conformation of any ZP module protein. Tel: +46 852480000 E-mail: Īssembly of extracellular filaments and matrices mediating fundamental biological processes such as morphogenesis, hearing, fertilization, and antibacterial defense is driven by a ubiquitous polymerization module known as zona pellucida (ZP) “domain”.
3 NTU Institute of Structural Biology, Nanyang Technological University, Singapore, Singapore.2 School of Biological Sciences, Nanyang Technological University, Singapore, Singapore.1 Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.
